AC Hotel San Francisco Airport/Oyster Point Waterfront

This stylish property — located within the Cove at Oyster Point — was the first new hotel to open in South San Francisco in 15 years. Celebrated as the birthplace of biotechnology, the city provides myriad demand generators like Genentech, Amgen, Onyx Pharmaceuticals, and Thermo Fisher Scientific.

Filled with local artwork and overlooking the San Francisco Bay, this AC Hotel features amenities such as 4,000 square feet of flexible meeting space and a full-service waterfront restaurant and lounge.The property is nestled on a calm inlet along a four-mile stretch of the San Francisco Bay Trail that is perfect for running, biking, and fishing. It’s just one mile from a Caltrain stop and BART station, offering guests easy access to San Francisco, AT&T Park, Pier 39, and The Embarcadero. SFO International Airport is three miles away.

Notably, this AC Hotel showcases a significant selection of masterworks created by artists associated with the progressive arts enclave of Black Mountain College. These pieces — paintings, works on paper, sculpture, and textiles — are on loan from the nationally acclaimed Johnson Collection.